焦雷课题组 | 清华大学 | labxing-凯发游戏网站

焦雷课题组

organic research lab focusing on mechanism, synthesis, and catalysis

our research consists of both mechanistic and synthetic studies in organic chemistry with an emphasis on in-depth mechanistic understanding. in particular, we focus on the key reactive intermediates in important reactions, wherein the elucidation of their structure, formation mechanism, and reaction pattern are the core content of our research. since 2014, we have been working on several representative reaction systems, and our studies have provided useful mechanistic insights that changed the established cognition of related fields and inspired the design of new reactions and catalysts.

chemistry

 background: diboron(4) compounds were prevalently employed in the borylation reactions. we have discovered that pyridine derivatives could catalyze the transition-metal-free borylation reaction of aryl halides with diboron(4) compounds. detailed mechanistic study revealed an unprecedented reaction mode of pyridine and diboron(4) in the presence of an alcoholate to generate a novel n-boryl pyridyl anion key intermediate, which was found to enable a series of new reactions that constitute...