瑕瑜研究组-自由基生物质谱

瑕瑜研究组-凯发游戏网站

welcome

our research program aims broadly at developing new mass spectrometry (ms) methods for bio-analysis. research efforts are currently focused on utilizing radical reactions as a unique approach to providing the high level of structural information of proteins and lipids, such as disulfide linkage pattern and carbon-carbon double bond location. we are also developing new ms instrumentation to investigate the radical attack on biomolecules in the gas phase and characterizing a series of peptide or protein radicals which are of biological importance. 

1. gas-phase radical ion chemistry

radical ions, which consist of unpaired electrons, offer distinct gas-phase ion chemistry as compared to the even-electron species. radical chemistry can be utilized to tackle challenging problems, such as differentiating isomeric structures, which would otherwise not be solved by traditional ms analysis of even-electron ions of the biomolecules. we are developing ms instrumentation and methods to facilitate radical reactions for either in the vacuum or in ambient air.

1. radical reactions...